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As studies have shown that approximately 40-50% of the root canal space remains untouched by conventional endodontic files, mechanical debridement alone cannot sufficiently clean and disinfect the root canal system. Chemical debridement in combination with mechanical debridement, also known as chemomechanical debridement, is necessary for successful root canal treatment. Irrigants are used to help dissolve vital and necrotic tissue, eradicate bacteria and other microorganisms, remove the smear layer, and lubricate the canal system. As no single irrigant exists that can accomplish all of the above goals, multiple solutions must be used during clinical treatment. Sodium hypochlorite (NaOCl), ethylenediamenetetraacetic acid (EDTA), and 2% Chlorhexidine (CHX) are commonly used for chemical debridement during the process of canal preparation.
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